John McCutcheon Genome biologist
John McCutcheon’s lab studies the diverse collections of microorganisms that are associated with insects, with a particular focus on interactions that are intimate and stable across evolutionary time. He is ultimately interested in the evolutionary forces that establish and maintain associations between organisms.
Most of his group studies the symbioses between sap-feeding insects and their intracellular bacterial symbionts. These symbioses rival organelle-host relationships in terms of cellular complexity and organismal integration, and this intimacy is reflected in the highly degenerate nature of the bacterial symbiont genomes. Indeed, all of the smallest bacterial genomes reported yet are from intracellular symbionts of sap-feeding insects. Because these symbionts cannot be cultured outside of their host insect, the McCutcheon lab relies heavily on comparative genomic and transcriptomic methods to study these systems. Much of the lab’s current focus is on understanding the role of the insect host, as well as any co-symbionts, in the functioning of bacterial symbionts with the most degenerate genomes.
P.J. Keeling et al, "Symbiosis becoming permanent: survival of the luckiest," Proceedings of the National Academy of Sciences USA 112, pp. 10101-10103, 2015.
M.A. Campbell et al, "Genome expansion via lineage splitting and genome reduction in the cicada endosymbiont Hodgkinia," Proceedings of the National Academy of Sciences USA 112, pp. 10192-10199, 2015.
J.T. Van Leuven et al, "Sympatric speciation in a bacterial endosymbiont results in two genomes with the functionality of one," Cell, vol. 158, no. 6, pp. 1270-1280, 2014.
J.P. McCutcheon and P.J. Keeling, "Endosymbiosis: Protein targeting further erodes the organelle/symbiont distinction," Curr. Biol., vol. 24, no. 14, pp. R654–R655, 2014.
F. Husnik et al, "Horizontal gene transfer from diverse bacteria to an insect genome enables a tripartite nested mealybug symbiosis," Cell, vol. 153, no. 7, pp. 1567–1578, 2013.
Fellow Integrated Microbial Biodiversity
University of MontanaDivision of Biological Sciences
PhD (Computational Biology) Washington University
MS (Human Genetics) University of Utah
BS (Biochemistry) University of Wisconsin
Ideas Related to John McCutcheon
Study reveals distinct and never-before-seen evolutionary path for bacteria living in animals