Brian Kobilka’s research is responsible for many advances in our understanding of how cell receptors function and respond to external signals. He is best known for his pioneering work on G-protein-coupled receptors (GPCRs), a family of receptors that include those in the eyes that are sensitive to light. Approximately half of all medications used today make use of GPCRs.
Kobilka is interested in the structure and mechanism of activation of GPCRs. His lab uses a range of biochemical and biophysical approaches, including protein crystallography and NMR and EPR spectroscopy, to provide additional insights into their dynamic properties and behaviours.
American Academy of Arts and Sciences, 2015
National Academy of Medicine, 2014
ASBMB Earl and Thressa Stadtman Distinguished Scientist Award, 2013
Nobel Prize in Chemistry, 2012
National Academy of Science, 2011
Rosenbaum, D. et al. "GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function." Science 318 (2007): 1266–1273.
Rasmussen, S. et al. "Crystal structure of the beta(2) adrenergic receptor-Gs protein complex." Nature 477 (2011): 549–55.
Nygaard, R. et al. "The Dynamic Process of beta(2)-Adrenergic Receptor Activation." Cell 152, no. 3 (January 2013): 532–42.
Huang, W. et al. "Structural Insights into μ-opioid receptor activation." Nature 524 (August 2015).
Manglik, A. et al. "Structural insights into the dynamic process of β2-adrenergic receptor signaling." Cell 161, no. 5 (2015): 1101–1111.