Janet Rossant



  • Advisor
  • Humans & the Microbiome


  • University of Toronto
  • Hospital for Sick Children
Department of Molecular Genetics


  • Canada


PhD (Mammalian Development), Cambridge University
BA (MA) Honours (Zoology), Oxford University


Janet Rossant, a developmental biologist, is an expert in stem cell research.
She studies the development of early mouse embryos to better understand human
embryonic and stem cell development. Her work on the genetic control of early development led to an understanding of the origins of pluripotent stem cells and the
discovery of trophoblast stem cells that give rise to the placenta. Rossant is intrigued by
the potential interactions between the maternal microbiome and stem cell origins.


Gairdner Wightman Award, 2015

DSc (honoris causa), University of British Columbia, 2014

Foreign Associate of the National Academy of Sciences (U.S.A.), 2008

Fellow of the Royal Society of London, 2000

Fellow of the Royal Society of Canada, 1993

Relevant Publications

Wong, A.P. et al. "Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein." Nat. Biotechnol. 30, no. 9 (September 2012): 876–82.

Yamanaka, Y. et al. "FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst." Development 137, no. 5 (March 2010): 715–24.

Chazaud, C. et al. "Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-Mapk pathway." Dev. Cell 10, no. 5 (May 2006): 615–24.

Niwa, H. et al. "Interaction between Oct3/4 and Cdx2 Determines trophectoderm differentiation." Cell 123, no. 5 (December 2005): 917–29.

Rossant, J., and P.P.L. Tam, eds. Mouse Development: Patterning, Morphogenesis, and Organogenesis. San Diego: Academic Press, 2002.


Rossant Lab