Jean-Philippe Julien studies the structure and function of immune cell surface proteins in order to find new vaccines and treatments for cancer and autoimmune diseases.
Surface glycoproteins on immune cells play critical roles that influence responses to invading pathogens. A better understanding of their atomic structure and the three-dimensional molecular complexes they form allow us to gain insight into their specific functions. This molecular understanding provides roadmaps to design improved vaccines, and treatments in cancer and autoimmune diseases.
Specifically, Julien uses a combination of biochemical, biophysical, immunological and structural techniques to study the B cell receptor, as well as antibodies and critical co-receptors on the B cell surface. His laboratory focuses on the characterization of B cell receptors by studies of their interactions with cognate molecules, therapeutics, and pathogens. The malaria parasite and HIV antigens are currently active areas of research in his laboratory. Together, these molecular studies uncover insights into dynamic immunity, one of life’s most intricate and essential systems.
Innovation and Science Early Researcher Award, Ontario Ministry of Research, 2019
Tier 2 Canada Research Chair in Structural Immunology, Canadian Institutes of Health Research, 2017
Post-Doctoral Fellowship, Canadian Institutes of Health Research, 2010
Doctoral Research Award, Canadian Institutes of Health Research, 2007
Scholarship for Master’s studies, Fonds Québécois de Recherche en Nature et Technologies (FQRNT), 2005