Paul Wiseman’s research interests lie at the interface between the physical and biological sciences. His work focuses on understanding the molecular mechanisms involved in how cells adhere to other cells and surfaces, and how cells regulate this adhesion to control cellular migration. He is also interested in developing new fluorescence fluctuation–based biophysical methods, such as image correlation spectroscopy and spatial intensity distribution analysis, to map protein transport and interactions in cells. Wiseman is also working on the application of nonlinear imaging modalities, such as second and third harmonic generation (SHG and THG) microscopy, for live cell and fixed tissue imaging.
Fulbright Visiting Chair at the California NanoSystems Institute, UCLA, 2015
J. D. Jackson Award for Excellence in Teaching (Physics), 2012
Keith Laidler Award in Physical Chemistry, 2009
Biophysical Society Young Fluorescence Investigator, 2005
Godin, A.G. et al. "Spatial intensity distribution analysis reveals abnormal oligomerization of proteins in single cells." Biophys. J. 109 (2015): 710–21.
Abu-arish, A. et al. "Cholesterol modulates CFTR confinement in the plasma membrane of primary epithelial cells." Biophys. J. 109 (2015): 85–94.
Lorenzo, L.E. et al. "Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite the Presence of GABAA Receptors." J. Neurosci. 34, no. 24 (June 2014): 8300–8317.
Bujold, K.E. et al. "Sequence-responsive unzipping DNA cubes with tunable cellular uptake profiles." Chem. Sci. 5, no. 6 (June 2014): 2449–2455.
Khazaei, M.R. et al. "Collapsin Response Mediator Protein 4 Regulates Growth Cone Dynamics through the Actin and Microtubule Cytoskeleton." J. Biol. Chem. 289, no. 43 (October 2014): 30133–30143.