Biochemist Philip Hieter is recognized for his work on structural and regulatory proteins that ensure faithful segregation of chromosomes during cell division.
His work has also demonstrated and advocated the value of yeast and other model experimental organisms for understanding mechanisms of human disease.
Genes that maintain genome structure are often mutated in cancer. Hieter’s laboratory has established an extensive catalogue of genes required for genome stability in yeast, which provides a resource to identify cross-species, candidate human genes that are somatically mutated in cancer. The lab has developed a strategy to identify genes in yeast synthetic lethal interaction networks, based on yeast CIN genes whose human counterparts are mutated in cancers, as a means for identifying novel therapeutic targets for targeted killing of cancer cells.
Fellow, American Academy of Arts and Sciences, 2012
President, Genetics Society of America, 2012
Fellow, American Association for the Advancement of Science, 2005
Fellow, Royal Society of Canada, 2005
Fellow, American Academy of Microbiology, 1998
Sikorski, R.S., and P. Hieter. "A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae." Genetics 122, no. 1 (1989): 19–27.