Sheena A. Josselyn

Sheena Josselyn


  • Fellow
  • Azrieli Brain, Mind & Consciousness


  • Hospital for Sick Children
Neurosciences & Mental Health


  • Canada


PhD (Psychology), University of Toronto
MA (Psychology), Queen's University


Sheena Josselyn studies how the brain encodes, stores and uses information.

Understanding how the brain processes information is not only a fundamental goal of
neuroscience, but also relevant to many brain information processing disorders,
spanning Alzheimer’s disease to autism spectrum disorder. Her research is
multidisciplinary, embracing methods, thinking and traditions from psychology to
molecular neuroscience to computational neuroscience. Josselyn is best known for her
findings on how (and where) the rodent brain forms memories. Specifically, she has
found that only a small subset of brain cells (neurons) are necessary for encoding any
one given memory. Ablating these cells can essentially ‘erase’ that memory, while
artificially activating them causes memory recall. Josselyn is interested in how these
fundamental processes interact with higher brain processes to mediate consciousness.


Daniel H. Efron Research Award from American College of Neuropsychopharmacology

Innovations in Psychopharmacology Award from Canadian College of

Brenda Milner Lecturer (University of Lethbridge)

Bryan Kolb Lecturer in Behavioural Neuroscience (University of Calgary)

Canada Research Chair (CRC) in brain circuits and cognition Tier I

Relevant Publications

Josselyn, S.A., S. Köhler, and P.W. Frankland. “Heroes of the engram.” Journal of Neuroscience 37 (2017): 4647–4657.
Rashid, A.S. et al. “Competition between engrams influences fear memory formation and recall.” Science 353 (2016): 383–87.

Hsiang, H. L. et al. “Manipulating a “cocaine engram” in mice.” Journal of Neuroscience 34 (2014): 14115–14127.

Han, J.H. et al. “Selective erasure of a fear memory.” Science 323 (2009):1492–1496.

Han, J.H. et al. “Neuronal competition and selection during memory formation.” Science
316 (2007): 457–60.