Research in Yaniv Ziv’s lab focuses on the mechanisms and dynamics underlying long-term memory.
The group is specifically interested in how memory information is coded in the brain, and about what happens, from the neural code’s perspective, to information stored in the brain over timescales that range from days to months: How do memory representations evolve as a function of time and experience? How do neuropsychiatric and degenerative disorders alter memory representations? How do plasticity mechanisms, such as adult neurogenesis, contribute to processing of memory information? The team investigates how memory information is coded by large neuronal populations in brain circuits that are important for memory processing. Group members do that by combining novel in-vivo optical imaging techniques for longitudinal recordings of neuronal activity in freely behaving rodents, genetic tools for manipulating neuronal activity in specific cell types, and computational approaches we develop for longitudinal analysis if neuronal activity data.
Sheintuch, L., Rubin, A., Brande-Eilat, N.,... Ziv, Y. (2017). Tracking the Same Neurons across Multiple Days in Ca2+ Imaging Data. Cell Reports, 21(4), 1102-1115. DOI: 10.1016/j.celrep.2017.10.013.
Rubin, A., Geva, N., Sheintuch, L., & Ziv, Y. (2015). Hippocampal ensemble dynamics timestamp events in long-term memory. eLife 2015;4:e12247 DOI: 10.7554/eLife.12247
Ziv, Y., & Ghosh, K.K. (2015). Miniaturized microscopes for large-scale imaging of neuronal dynamics in freely behaving animals. Current Opinion in Neurobiology, 32, 141-47. DOI: 10.1016/j.conb.2015.04.001.
Chen, J.L., Andermann, M. L., Keck, T., Xu, N. & Ziv, Y. (2013). Imaging neuronal populations in behaving rodents: Paradigms for studying neural circuits underlying behavior in the Mammalian cortex. Journal of Neuroscience, 33(45), 17631-17640 DOI: https://doi.org/10.1523/JNEUROSCI.3255-13.2013
Ziv, Y., Burns, L. D., Cocker, E. D., et al. (2013). Long-term kinetics of CA1 hippocampal place codes. Nature Neuroscience, 16(3):264-6. doi: 10.1038/nn.3329