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Yue Wan

Yue Wa

Appointment

  • CIFAR Azrieli Global Scholar 2018
  • Molecular Architecture of Life

Institution

  • Genome Institute of Singapore
Stem Cell and Development

Country

  • Singapore

Education

PhD (Cancer Biology), Stanford University
BS (Biochemistry and Cell Biology), University of California, San Diego

About

Just like origami, RNA can fold into different shapes that drives its functions in the cell.

Accurate folding of RNA is critical for proper functioning and misfolding can lead to disease. As the cell is made up of millions of RNA molecules, we develop ways to rapidly study RNA shapes, how they can be altered in different environments and be used to interact with other cellular parts for proper functioning. Knowing the configuration of RNA shapes in pathogens allows us to design components that can block or distort them, slowing down their pathogenic growth, and facilitating treatments in infectious diseases. 

Awards

EMBO Young Investigator, 2017
L’Oreal-UNESCO for Women in Science, National Fellowship (Singapore), 2016
A*STAR Investigatorship, 2016
Singapore National Academy of Science- Young Scientist Award, 2015
Society in Science- Branco Weiss Fellowship, 2014

Relevant Publications

Tapsin, S. et al. "Genome-wide identification of natural RNA aptamers in prokaryotes and eukaryotes." Nature Communications 9,1 (2018): 1289.

Aw, J.G.A.*, A. Wilm*, S. Miao*, S. Yang, N.L. Xin, B. Kum-Loong, C. Yun-Shen, Z. Tong, S. Tapsin, T. T. Susanto, N. Nagarajan and Y. Wan. "In vivo mapping of eukaryotic RNA interactomes reveals principles of higher-order organization and regulation." Molecular Cell 62,4 (2016): 603-17.

Wan, Y.*, K. Qu*, Q. C. Zhang, O. Manor, Z. Ouyang, Jiajing Zhang, Michael P. Snyder, Eran Segal and Howard Y. Chang. "Landscape and variation of RNA secondary structure across the human transcriptome." Nature 505, 7485 (2013): 706-9.

Yue Wan, Kun Qu, Michael Kertesz, Zhengqing Ouyang, Jun Li, Robert Tibshirani, Robert C. Nutter, Eran Segal, Howard Y. Chang. "Genome-wide measurement of RNA folding energies." Molecular Cell 48,2 (2012):169-81.

Kertesz, M.*, Y. Wan*, E. Mazor, J. L. Rinn, R. C. Nutter, H. Y. Chang, E. Segal. "Genome-wide Measurement of RNA Secondary Structure in Yeast."  Nature 467,7311 (2010): 103-7.

* these authors contributed equally.

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