|Location:||Autodesk Technology Centre, MaRS Centre, Toronto|
Utilizing Genetic Networks to Decode Complex Disease
The future of genetic networks is here. What methodological and conceptual approaches can we use to further decipher and attribute gene variants to complex traits? How can this knowledge be used and integrated to understand disease etiology and the longer-term pursuit of precision medicine?
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Nearly all human disease has a genetic foundation. A fundamental goal of genetics is to understand how genetic variation leads to phenotypic variation. Considerable advancements have been made in reaching this goal, yet the complexity of genetic interactions (in both coding and non-coding regions), as well as environmental determinants of complex disease makes it challenging to fully attribute genetic causality, predict predisposition, and advance whole-genome precision medicine. A deeper understanding of how the accumulation of small genetic effects and gene interactions give rise to the overall functioning of a cell will continue to bring the broader genetics community closer to this goal.
On June 4 – 5, 2018, CIFAR’s program in Genetic Networks, in partnership with GET, will be hosting a GETx conference to explore emerging research questions and visionary ideas on gene variants and the larger genetic networks they belong within, in order to better understand complex disease. International thought leaders from research, healthcare and industry will deliberate together on how genetic interactions give rise to phenotypes, by examining this topic through various experimental designs and conceptual approaches that have the potential to drive precision medicine.
The CIFAR-GETx Conference is sponsored by the University of Toronto McLaughlin Centre and Autodesk. The conference is an affiliate event of GET, an annual forum to debate the technical, commercial, and societal impacts of advances in our ability to measure and understand people and their traits.
Please find a speaker list below and check back soon as more will be announced.
JUNE 4, 2018
8:00 – Breakfast
8:30 – Welcome and stage setting for conference
9:00 – Keynote address
George Church, Harvard University
9:45 – Coffee Break
10:15 – Session 1: Complex Factors That Influence Genotype to Phenotype
Discussion moderator: Hannah Carter, CIFAR Azrieli Global Scholar, University of California, San Diego
• Jasper Rine, University of California, Berkeley
• David Kelley, Calico
• Trey Ideker, University of California, San Diego
11:00 – Moderated Panel Q&A
11:45 – Lunch
12:45 – Session 2: Genetic Interactions, Penetrance and Human Disease
Discussion moderator: Stephen Scherer, CIFAR Senior Fellow, McLaughlin Centre for Molecular Medicine, University of Toronto
• Jason Moffat, CIFAR Senior Fellow, University of Toronto
• Adam Shlien, Hospital for Sick Children
• Shamil Sunyaev, Harvard Medical School
1:30 – Moderated Panel Q&A
2:15 – Coffee Break
2:45 – Session 3: Disruptive Technologies
Discussion moderator: Hu Li, Mayo Clinic
• Brenda Andrews, CIFAR Senior Fellow, University of Toronto
• Jennifer Listgarten, University of California, Berkeley
• Prashant Mali, Engine Biosciences
3:30 – Moderated Panel Q&A
4:15 – Discussion and Synthesis of Day 1
5:00 – Reception at JLABS, MaRS
JUNE 5, 2018
8:00 – Breakfast
8:30 – Welcome, Stage Setting for Day 2
9:00 – Session 4: Natural Variation and Population Genetics
• Nancy Cox, Vanderbilt University
• Unnur Thorsteinsdottir, DeCODE
9:40 – Moderated Panel Q&A
10:25 – Coffee Break
10:55 – Session 5: Breaking Down Silos Between Academia, Industry and The Clinic – Model Systems To Human Populations
Discussion moderator: Andrew Hessel, Humane Genomics Inc.
• Calum MacRae, Harvard University
• Gustavo A. Stolovitzky, IBM Research
• Marc Fiume, DNAStack
11:40 – Moderated Panel Q&A
12:20 – Discussion and Synthesis of Day 2
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