Brenda Andrews’ current research interests include mechanisms of cell division control and polarity and functional genomics. Determining how combinations of genetic variants or perturbations manifest themselves, particularly in the context of human disease, is a formidable challenge. To address this challenge, the Andrews lab is collaborating with Charles Boone’s group to understand how genes interact. To do this, they are using a simple model system, the single-celled budding yeast; yeast is not only famous to beer- and wine-makers, but is also celebrated as a premier model system for understanding the basics of human biology. The Andrews laboratory is also studying how cells divide. It has become clear that the machinery that controls cell division is universally subverted in cancer cells. We aim to understand how the cell cycle is regulated, with the overarching goal of contributing to the world-wide effort to design better cancer therapies.
Women in Science and Engineering “Breaking the Glass Ceiling” Award, University of Toronto, 2007.
Fellow, Royal Society of Canada, 2005.
Premier's Research Excellence Award, 1999-2002.
Medical Research Council of Canada Scientist, 1997-2002.
Medical Research Council of Canada Fellowship, 1986-1989.
Sopko, R., Huang, D., Smith, J.C., Figeys, D. Andrews, B. (2007). Activation of the Cdc42p GTPase by cyclin-dependent protein kinases in budding yeast. EMBO Journal, in revision (April 2007).
Haynes, J., Garcia, B., Stollar, E., Rath, A., Andrews, B., Davidson, A. (2007). The biologically relevant targets and binding affinity requirements for the function of the yeast Abp1p SH3 domain vary with genetic context, Genetics 176, 193-208.
Moffat, J. and Andrews, B. (2004). Essential control of cell morphogenesis in budding yeast by late G1 cyclin-Cdk activity, Nature Cell Biology 6, 59-66
Costanzo, M., Schub, O. and Andrews, B. (2003). G1 transcription factors are differentially regulated in S. cerevisiae by the Swi6-binding protein Stb1, Mol. Cell. Biol., 23, 5064-5077.
Humphries, C., Goode, B. and Andrews, B. (2001). Regulation of the actin and arp2/3 complex associated protein, coronin, by phosphorylation. Cold Spring Harbor meeting on Yeast Cell Biology. August 14-19, Cold Spring Harbor, N.Y. (C. Humphries, poster presentation)
Senior Fellow Genetic Networks
University of TorontoDepartment of Medical Research; Terrence Donnelly Centre for Cellular & Biomolecular Research
PhD (Medical Biophysics) University of Toronto