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Brian Kobilka

Brian Kobilka’s research is responsible for many advances in our understanding of how cell receptors function and respond to external signals. He is best known for his pioneering work on G protein-coupled receptors (GPCRs), a family of receptors that include those in the eyes that are sensitive to light. Approximately half of all modern medications used today make use of GPCRs.

Kobilka’s research interests are the structure and mechanism of activation of GPCRs. His lab uses a range of biochemical and biophysical approaches, including protein crystallography, NMR and EPR spectroscopy, to provide additional insights into their dynamic properties and behaviours.

Awards

Elected to the American Academy of Arts and Sciences, 2015.

Elected to National Academy of of Medicine, 2014.

ASBMB Earl and Thressa Stadtman Distinguished Scientist Award, 2013.

The Nobel Prize in Chemistry, 2012.

Elected to the National Academy of Science, 2011.

Relevant Publications

D. Rosenbaum et al, "GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function," Science, vol. 318, pp. 1266-1273, 2007.

S. Rasmussen, et al, "Crystal structure of the beta(2) adrenergic receptor-Gs protein complex," Nature, vol. 477, pp. 549-555, 2011.

R. Nygaard et al, "The Dynamic Process of beta(2)-Adrenergic Receptor Activation," Cell, vol. 152, no, 3, pp. 532-542, Jan. 2013.

W. Huang et al, "Structural Insights into μ-opioid receptor activation," Nature, Aug. 2015.

A. Manglik et al, "Structural insights into the dynamic process of β2-adrenergic receptor signaling," Cell, vol. 161, no. 5, pp. 1101-1111, 2015.

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Appointment

Advisor Molecular Architecture of Life

Institution

Stanford UniversityMolecular and Cellular Physiology and Medicine

Education

MD Yale University

BS (Biology, Chemistry) University of Minnesota Duluth

Country

United States

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