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Corinne Maurice

My works aims to determine how bacteriophages, viruses that only infect bacteria, regulate the activity of the trillions of bacteria naturally present in the human gut. As humans, we are walking microbial systems: trillions of microbial cells are found on our skin, mouth, gut, and they are essential for our health. Changes in the diversity and function of these microbial cells have severe consequences for our health: obesity, diabetes, inflammatory bowel diseases, autism, allergies, … All these conditions could be controlled and potentially cured if we could regulate the metabolism of our gut bacteria (the gut microbiota). I pioneered the use of single cell tools and approaches developed in environmental microbiology and ecology to understand how bacteria respond to environmental changes and interact with their viral predators in the human gut. I have demonstrated that common therapeutic drugs could rapidly alter bacterial activity, possibly explaining individual side effects to the same therapeutic treatments. My lab is currently taking these approaches further to link bacterial diversity to specific functions and explore how phage infection changes these patterns.

Awards

Tier 2 Canada Research Chair in gut microbial physiology, 2015-2020.

French MESR Doctoral Fellowship, 2006-2009.

Mauritian – French Excellence Undergraduate Scholarship, 2001-2006.

Relevant Publications

M. Taguer and C.F. Maurice, "The complex interplay of diet, xenobiotics, and microbial metabolism in the gut: implications for clinical outcomes," Clin Pharmacol Ther;99(6): 588-99, 2016.

C.F. Maurice et al,. "Marked seasonal variation in the wild mouse gut microbiota," ISME J;9(11):2423-34, 2015

L.A. David et al., "Diet rapidly and reproducibly alters the human gut microbiome," Nature;505:559-63, 2014

C.F. Maurice and P.J. Turnbaugh, "Quantifying the metabolic activities of human-associated microbial communities across multiple ecological scales," FEMS Microbiol Rev;37(5):830-48, 2013.

C.F. Maurice, H.J. Haiser and P.J. Turnbaugh, "Xenobiotics shape the physiology and gene expression of the active human gut microbiome," Cell;152(1-2):39-50., 2013

Connect

Appointment

CIFAR Azrieli Global Scholar Humans & the Microbiome

Institution

McGill UniversityDepartment of Microbiology and Immunology

Education

PhD (Aquatic microbial ecology) Universite de Montrepplier 2

Licence de Biologie des Organismes Universite de Montrepplier 2

Country

Canada

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