Daniel Figeys seeks to determine how changes in proteins, their modifications and their interactions affect human health. As well, he is interested in using -omics based approaches to understand changes in systems. His laboratory is currently working on projects aimed at better understanding protein changes in the brain. In particular, he is studying the fundamental principle of the circadian clock, the effect of aging on the brain, as well as changes in models of Parkinson’s disease by proteomics. His laboratory is also investigating, in collaboration with a microbiologist and a clinician, the host-microbiome interactions and their roles in Inflammatory Bowel Disease. He is also studying functional classes of proteins including protein convertases and the SMYD family of lysine methyl transferases and their roles in diseases. Finally, his laboratory develops new technologies to study minute levels of proteins and post-translational modifications.
Canada Research Chair in Proteomics and Systems Biology, 2004.
Visiting Professor for Senior International Scientists, Chinese Academy of Sciences
Ken Standing Award
C.K. Chiang et al., "The proteomic landscape of the suprachiasmatic nucleus clock reveals large-scale coordination of key biological processes," PLoS Genet. 10(10):e1004695. doi: 10.1371/journal.pgen.1004695. eCollection, PMID:25330117, Oct 2014
M. Abu-Farha"Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2," J Mol Cell Biol., 3(5):301-8. doi: 10.1093/jmcb/mjr025.PMID:22028380, 3 Oct 2011
J.p. Lambert, "Defining the budding yeast chromatin-associated interactome," Mol Syst Biol., 6:448. doi: 10.1038/msb.2010.104, 21 Dec 2010
R.M. Ewing, "Large-scale mapping of human protein-protein interactions by mass spectrometry," Mol Syst Biol., 3:89, 2007
Senior Fellow Molecular Architecture of Life
University of OttawaFaculty of Medicine, Department of Biochemistry, Microbiology & Immunology
Ph.D. Chemistry University of Alberta
M.Sc. Chemistry Université de Montréal
B.Sc. Chemistry Université de Montréal
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