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Daniel J Müller

It is one pertinent demand in life sciences, systems biology and synthetic biology to characterize how molecular interactions drive biological processes and to decipher the physical principles of this biological language. The research group of Daniel Müller develops bionanotechnological methods that allow quantifying inter- and intramolecular interactions of biological processes. Currently these methods allow to quantify and structurally localize interactions that fold, stabilize, and control the functional state of single proteins in the cellular membrane. Furthermore, it became possible to image cells at nanometer resolution, to quantify and localize cellular interactions at molecular resolution, and to observe how individual receptors of living cells communicate and collectively contribute to basic cellular processes.


Chair of Biophysics, Department of Biosystems Science and Engineering, ETH Zürich Switzerland, 2010.

Full professor for Cellular Machines (C4-position) at the Biotechnology Center, University of Technology Dresden Germany, 2002-2010.

Director of the Biotechnology Center, Dresden Germany, 2003-2005.

Groupleader (C3-position) at the Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden Germany, 2000-2002.

Relevant Publications

J. Thoma et al, "‘Impact of holdase chaperones Skp and SurA on the folding of β-barrel outer membrane proteins’," Nature Structural and Molecular Biology (2015), in press.

D. Alsteens et al, "‘Imaging G protein-coupled receptors while quantifying their ligand-binding free-energy landscape’," Nature Methods (2015), in press.

J.M. Nunes et al, "'Action of the Hsp70 chaperone system observed with single proteins’ Nature Communications," vol 6, pp. 6307, 2015.

S.P. Ramanathan et al, " ‘Cdk1 dependent mitotic enrichment of cortical myosin II promotes cell rounding against confinement’,"Nature Cell Biology, vol. 17, pp. 148-159, 2015.

T. Serdiuk et al, "‘Substrate-induced changes in the structural properties of LacY’," Proc. Natl. Acad. Sci. USA, vol. 111, pp. E1571-E1580, 2014.



Advisor Molecular Architecture of Life


ETH ZürichBiosystems Science and Engineering


Habilitation (Venia docendi) in Biophysics University of Basel, Switzerland

PhD (Biophysics) University of Basel, Switzerland

M.Sc. (Biology) University of Basel, Switzerland

M.Sc. (Physics) University of Technology (TU) Berlin



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