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David Stuart Structural biology, Virology, Viral proteins, Viruses, X-ray, Crystallography

David I. Stuart’s research interests include the structure of viruses, viral proteins, and cellular proteins that interact with viruses. He has made many important contriubtions to the study of structural virology, including the determination of the structures of foot-and-mouth disease virus, bluetongue virus and the membrane-containing phages PRD1 and PM2. His work has set new records for atomic resolution of such large and complex structures. Stuart also colalborates on a number of projects investigating how viruses interact with receptors and how they evolve.

Awards

Max Perutz Prize, European Crystallographic Association, 2007.

Aminoff Prize, Royal Swedish Academy of Sciences, 2006.

Elected Fellow of the Academy of Medical Sciences, 2006.

Elected Fellow of the Royal Society, 1996.

Relevant Publications

H. M. Ginn et al, "A revised partiality model and post-refinement algorithm for X-ray free-electron laser data," Acta Crystallogr. Sect. D: Biol. Crystallogr., vol. 71, no. 6, pp. 1400-1410, June 2015.

R.J. Gildea et al, "New methods for indexing multi-lattice diffraction data," Acta Crystallogr. Sect. D: Biol. Crystallogr., vol. 70 (Pt. 10), pp. 2652-2666, Oct. 2014.

X. Wang et al, "Hepatitis A virus and the origins of picornaviruses," Nature, vol. 517, pp. 85-88, Oct. 2014.

K. El Omari et al, "Unexpected structure for the N-terminal domain of hepatitis C virus envelope glycoprotein E1," Nat. Commun., vol. 16, no. 5, pp. 4874, Sept. 2014.

L. De Colibus et al, "More powerful virus inhibitors from structure-based analysis of HEV71 capsid-binding molecules," Nat. Struct. Mol. Biol., vol. 21, no. 3, pp. 282-288, March 2014.

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Appointment

Advisory Committee Chair Molecular Architecture of Life

Institution

University of OxfordNuffield Department of Medicine

Education

PhD (Biochemistry) Bristol University

BSc (Biophysics) Kings College London

Country

United Kingdom

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