Donald Moerman Biologist
Donald Moerman is interested in the development of cell identity and tissue function in the model organism C. elegans. As Director of the C. elegans knockout Facility he works in collaboration with an international team to provide knockout strains for the C. elegans community. Currently he is developing rich mutant libraries (Million Mutation Project resource) using Deep Sequencing and also developing new gene knock out procedures using CRISPR/Cas9 nucleases. His most recent project involves developing C. elegans as a platform for anthelmintic drug discovery.
UBC Killam Faculty Research Fellowship, 1993.
S. Flibotte et al, "Whole-Genome profiling of mutagenesis in Caenorhabditis elegans," Genetics, vol. 185, pp. 431-441, 2010.
M.R. Lowden, "Complex rearrangements promote end-to-end chromosome fusion in C. elegans telomerase mutants," Science, vol. 332, pp. 468-471, 2011.
R. Barstead et al, "Large-scale screening for targeted knockouts in the Caenorhabditis elegans genome," G3, vol. 2, pp. 1415-25, 2012.
O. Thompson et al, "The Million Mutation Project: A new approach to genetics in Caenorhabditis elegans," Genome Research, vol. 23, pp. 1749-62, 2013.
H. Hutter and D. Moerman, "Big Data in C. elegans : Quo Vadis?" Mol. Biol. Cell. (In Press), Nov. 2015.
Senior Fellow Genetic Networks
University of British ColumbiaDepartment of Zoology
PhD (Biology) Simon Fraser University
BSc (Biology) Simon Fraser University
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