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Janet Rossant Developmental Biologist

Janet Rossant is an expert in stem cell research who studies the development of early mouse embryos to better understand human embryonic and stem cell development. Her work on the genetic control of early development led to an understanding of the origins of pluripotent stem cells and the discovery of trophoblast stem cells that give rise to the placenta. She is intrigued by the potential interactions between the maternal microbiome and stem cell origins.

Awards

Gairdner Wightman Award, 2015.

DSc (honoris causa), University of British Columbia, 2014.

Foreign Associate of the National Academy of Sciences USA, 2008.

Fellow of the Royal Society of London, 2000.

Fellow of the Royal Society of Canada, 1993.

Relevant Publications

A.P. Wong et al, "Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein," Nat. Biotechnol., vol. 30, no. 9, pp. 876-882, Sept. 2012.

Y. Yamanaka et al, "FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst," Development, vol. 137, no. 5, pp. 715-724, March 2010.

C. Chazaud et al, "Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-Mapk pathway," Dev. Cell, vol. 10, no. 5, pp. 615-624, May 2006.

H. Niwa et al, "Interaction between Oct3/4 and Cdx2 Determines trophectoderm differentiation," Cell, vol. 123, no. 5, pp. 917-929, Dec. 2005.

A. Nagy et al, "Derivation of completely cell culture-derived mice from early-passage embryonic stem cells," Proc. Natl. Acad. Sci. U.S.A., vol. 90, no. 18, pp. 8424-8428, Sept. 1993.

Books

J. Rossant and P.P.L. Tam, Eds., Mouse Development: Patterning, Morphogenesis, and Organogenesis. San Diego: Academic Press, 2002.

Connect

Appointments

Program Co-Director Humans & the Microbiome

Senior Fellow Humans & the Microbiome

Institution

Hospital for Sick Children, University of TorontoMolecular Genetics

Education

PhD (Mammalian Development) Cambridge University

BA (MA) Honours (Zoology) Oxford University

Country

Canada

Ideas Related to Janet Rossant

Child & Brain Development | Research Brief

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Child & Brain Development | Announcement

Janet Werker wins award for work on language acquisition

The Social Sciences and Humanities Research Council has awarded CIFAR Senior Fellow Janet Werker its highest honour, the Gold Medal...

Humans & the Microbiome | News

CIFAR researcher and Board members appointed to the Order of Canada

CIFAR Senior Fellow Janet Rossant and Board Members Stephen Toope and James Dinning have been honoured for their scholarship, leadership,...

Announcement

CIFAR revs up collaborations in four new programs

CIFAR’s four new programs are having their first collaborative meetings, delving into questions such as how to improve solar energy, define the complexities of human consciousness, and improve health through a better understanding of microbes and the molecular basis of life.

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How a mother’s depression affects language development in babies

By the time a baby is born, she is capable of learning any of the world’s languages. In the following...