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Janet Rossant Developmental Biologist

Janet Rossant is an expert in stem cell research who studies the development of early mouse embryos to better understand human embryonic and stem cell development. Her work on the genetic control of early development led to an understanding of the origins of pluripotent stem cells and the discovery of trophoblast stem cells that give rise to the placenta. She is intrigued by the potential interactions between the maternal microbiome and stem cell origins.


Gairdner Wightman Award, 2015.

DSc (honoris causa), University of British Columbia, 2014.

Foreign Associate of the National Academy of Sciences USA, 2008.

Fellow of the Royal Society of London, 2000.

Fellow of the Royal Society of Canada, 1993.

Relevant Publications

A.P. Wong et al, "Directed differentiation of human pluripotent stem cells into mature airway epithelia expressing functional CFTR protein," Nat. Biotechnol., vol. 30, no. 9, pp. 876-882, Sept. 2012.

Y. Yamanaka et al, "FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst," Development, vol. 137, no. 5, pp. 715-724, March 2010.

C. Chazaud et al, "Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-Mapk pathway," Dev. Cell, vol. 10, no. 5, pp. 615-624, May 2006.

H. Niwa et al, "Interaction between Oct3/4 and Cdx2 Determines trophectoderm differentiation," Cell, vol. 123, no. 5, pp. 917-929, Dec. 2005.

A. Nagy et al, "Derivation of completely cell culture-derived mice from early-passage embryonic stem cells," Proc. Natl. Acad. Sci. U.S.A., vol. 90, no. 18, pp. 8424-8428, Sept. 1993.


J. Rossant and P.P.L. Tam, Eds., Mouse Development: Patterning, Morphogenesis, and Organogenesis. San Diego: Academic Press, 2002.



Program Co-Director Humans & the Microbiome

Senior Fellow Humans & the Microbiome


Hospital for Sick Children, University of TorontoMolecular Genetics


PhD (Mammalian Development) Cambridge University

BA (MA) Honours (Zoology) Oxford University



Ideas Related to Janet Rossant

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