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John Vederas Chemist

John Vederas seeks to understand the chemistry by which Nature assembles biological molecules, not only as an exciting intellectual endeavour, but also as prerequisite to rationally influence life processes in medicine and agriculture. His research currently centers on the formation of important biological molecules, including antimicrobial peptides, amino acid metabolites, and polyketides. The approach is interdisciplinary. Experimental aspects of our projects encompass organic synthesis and spectroscopic methodology (especially NMR and mass spectrometry), as well as isotopic techniques, natural products isolation, enzymatic reactions, molecular biology, bioinformatics and culturing of microorganisms. Current projects include structures and mechanisms of peptides with cardiovascular or antibiotic acitivity against pathogens resistant to current therapy, formation of fungal polyketides including cholesterol lowering agents such as lovastatin and simvastatin, and mechanisms of enzymes that catalyze unusual processes (e.g. conversion of the anticholinergic drug atropine to scopolamine).

Awards

Fellow of the American Academy of Microbiology, 2014.

Fellow of the Royal Society (London), 2009.

Chemical Institute of Canada (CIC) Medal, 2008.

University Professor of Chemistry (Univ Alberta), 2000.

Fellow of the Royal Society of Canada, 1997.

Relevant Publications

R.V.K. Cochrane, et al., "Production of new cladosporin analogues by reconstitution of the polyketide synthases responsible for the biosynthesis of this antimalarial agent," Angew. Chemie Int. Ed. 55, pp. 664-668 (2016)

R.V.K. Cochrane and J.C. Vederas, "Highly selective but multifunctional oxygenases in secondary metabolism," Accts. Chem. Res. 47, pp. 3148-3161 (2014)

C.T. Lohans, J.L. Li and J.C. Vederas, "Structure and Biosynthesis of Carnolysin, a Homolog of Enterococcal Cytolysin with D-Amino Acids," J. Am. Chem. Soc. 136, pp. 13150-13153 (2014)

C.T. Lohans, et al., "Structural Characterization of the Highly Cyclized Lantibiotic Paenicidin A via a Partial Desulfurization/Reduction Strategy," J. Am. Chem. Soc. 134, pp. 19540-19543 (2012)

W. Liu, et al., "Solid Supported Chemical Syntheses of Both Components of the Lantibiotic Lacticin 3147," J. Am. Chem. Soc. 133, pp. 14216-14219 (2011)

Books

J.C. Vederas, (Ed), Amino Acids, Peptides & Proteins, Volume 5 of Comprehensive Natural Products II Chemistry and Biology, Oxford, Elsevier, 752 pages, ISBN 978-0-08-045381-1, 2010

F.J. Leeper and J.C. Vederas, (eds), Aromatic Polyketides, Isoprenoids and Alkaloids, Volume II - Topics in Current Chemistry, Springer-Verlag, Vol 209, 247 pages, ISBN 3-540-66573-0, 2000

F.J. Leeper and J.C. Vederas, (eds), Biosynthesis - Polyketides and Vitamins - Desktop Editions in Chemistry, Springer-Verlag, Berlin, 193 pages, ISBN 3-540-66969-8, 2000

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Appointment

Senior Fellow Molecular Architecture of Life

Institution

University of AlbertaDepartment of Chemistry

Education

B.Sc. in Chemistry Stanford University

Ph.D. in Organic Chemistry (synthesis) Massachusetts Institute of Technology

Country

Canada

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