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Joseph Heitman Microbiologist & Geneticist

Joseph Heitman’s research focuses on the evolution of sex in fungi and the roles of sexual reproduction in microbial pathogens and how cells sense and respond to nutrients and the environment. He is also interested in the targets and mechanisms of action of immunosuppressive and antimicrobial drugs, including the discovery of TOR as a globally conserved nutrient sensor inhibited by the antiproliferative drug rapamycin, and the genetic and molecular basis of microbial pathogenesis and development.

Awards

NIH/NIAID MERIT Award, 2011-2021.

Elected member of the Association of American Physicians, 2006.

Elected Fellow of the American Association for the Advancement of Science, 2004.

Elected Fellow of the American Academy of Microbiology, 2004.

Elected member of the American Society for Clinical Investigation, 2003.

Squibb Award from the Infectious Diseases Society of America, 2003.

AMGEN Award from the American Society for Biochemistry and Molecular Biology, 2002.

Relevant Publications

J. Heitman et al, "Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science, vol. 253, pp. 905-909, 1991.

X. Lin et al, "Sexual reproduction between partners of the same mating-type in Cryptococcus neoformans," Nature, vol. 434, pp. 1017-1021, 2005.

A. Idnurm et al, ". Identification of the sex genes in an early diverged fungus," Nature, vol. 451, pp. 193-196, 2008.

J. Heitman, "Evolution of eukaryotic microbial pathogens via covert sexual reproduction," Cell Host & Microbe, vol. 8, pp. 86-99, 2010.

S. Calo et al, "Antifungal drug resistance evoked via RNAi-dependent epimutations," Nature, vol. 513, pp. 555-558, 2014.

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Appointment

Advisor Integrated Microbial Biodiversity

Institution

Duke UniversityJames B. Duke Professor and Chair, Department of Molecular Genetics and Microbiology

Education

PhD Rockefeller University

MD Cornell University Medical College

BSc, MS University of Chicago

Country

United States

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