Michael E. Grigg Parasitologist
Michael Grigg’s research program investigates the evolution, phylogenetics, biochemistry, and immunopathogenesis of prevalent zoonotic parasites (animal parasites that can infect humans) including, diplomonads, stremenopiles, amoebozoa, parabasalids, kinetoplastids, and the apicomplexa. They perform whole genome sequencing, population genetic, biochemical and molecular epidemiology analyses to identify protozoal agents associated with epidemic disease, and use both forward and reverse genetics to identify genetic and metabolic determinants governing virulence shifts among the parasitic protozoa.
Grigg’s program’s work in immunopathogenesis in Toxoplasma has identified parasite effector molecules that activate inflammasome pathways, and dysregulate CD4 T cell and B cell activation. Grigg utilizes pathogen driven models of immune dysregulation to study B cell homing, regulatory T cell function, and the gut microbiota in the regulation and maintenance of immune homeostasis in the context of inflammatory stimuli that contribute to or maintain the chronicity of intestinal inflammation. His program’s research is contributing valuable insight into parasite-specific molecular strategies of eukaryotic pathogenesis.
Canada Foundation for Innovation New Opportunities Award, 2004-2010.
Recipient of CIHR's New Investigator Award, 2004-2009.
Selected as a Scholar of the Michael Smith Foundation for Health Research, 2002.
Fellow Integrated Microbial Biodiversity
National Institutes of HealthLaboratory of Parasitic Diseases
PhD (Biochemistry) Imperial College of Science, Technology & Medicine
BSc (Biochemistry) University of British Columbia
Ideas Related to Michael E. Grigg
Mounting evidence shows that the ecosystem of microscopic creatures that inhabit the mammalian gut have a major influence on health....