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Michael S. Kobor Medical geneticist

Research in Michael Kobor’s laboratory is focused on the epigenetic regulation of gene expression and genome function. Particular emphasis is placed on understanding the mechanistic nature of these processes and their modulation by environmental exposures.

Kobor’s research team utilizes an interdisciplinary approach, with investigations spanning the entire spectrum from model organisms to human populations. Through a variety of research approaches, ongoing work in Kobor’s laboratory touches on some of the fundamental questions in chromatin biology. These queries include how distinct chromosomal neighbourhoods are established, how they function and interact with enzymes involved in DNA metabolism, what the functional differences between histone variants and canonical histones are, and how chromatin-remodeling complexes are regulated. Most recently, working with his research team and interdisciplinary collaborators, Kobor has begun investigating epigenetic variation in humans, with a particular focus on the effects of social environment on lifelong health and aging. These studies aim to decipher the mechanisms by which environmental exposures and life experiences can “get under the skin” to regulate the activity of genes and contribute to human physiology and behaviour during the life course of an individual.

Awards

Sunny Hill BC Leadership Chair in Child Development, Leading Edge Endowment Fund (LEEF), 2016.

Connaught Global Challenge Distinguished Visiting Professor at the Fraser Mustard Institute for Human Development, University of Toronto, 2013.

Canada Research Chair Tier 1, Canadian Institutes of Health Research, 2014.

CFRI Member Recognition Award of Excellence in Biomedical Research, Child and Family Research Institute, 2013.

Relevant Publications

M.S. Kobor and J. Greenblatt, "Regulation of transcription elongation by phosphorylation," Biochim. Biophys. Acta, vol. 1577, no. 2, pp. 261-275, Sept. 2002.

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Appointment

Senior Fellow Child & Brain Development

Institution

University of British ColumbiaDepartment of Medical Genetics

Education

PhD (Medical Genetics) University of Toronto

Biology Diploma University of Heidelberg

Country

Canada

Ideas Related to Michael S. Kobor

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