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Mikko Taipale

Dr. Mikko Taipale is fascinated with the birth, life, and death of proteins. Right after their birth, all proteins need to adopt their intricate three-dimensional shape and find the right localization in the cell. They do so with the help of an ancient network of highly conserved chaperones and co-chaperones. After adopting the right shape in the right place, all proteins must then interact with other proteins and biomolecules within the greater context of cellular interaction networks. And when their time has come, all proteins must be degraded in an orderly manner through the ubiquitin-proteasome system. Dr. Taipale’s laboratory is using modern high-throughput functional proteomics tools to characterize how these networks of chaperones, co-chaperones, and the ubiquitin-proteasome system are organized and how protein/protein interaction specificity is achieved in the crowded environment of the cell. In particular, Dr. Taipale is interested in understanding how these networks are rewired in cancer and in rare Mendelian disorders. In addition, the Taipale laboratory has a strong emphasis on technology development for detecting and characterizing new biomolecular interactions.

Awards

Canada Research Chair in Functional Proteomics and Proteostasis, 2016.

Ontario Research Foundation Early Researcher Award, 2016.

Margaret and Herman Sokol Postdoctoral Award, 2012.

Human Frontier Science Program Postdoctoral Award, 2007.

Relevant Publications

Sahni et al, "Widespread macromolecular interaction perturbations in human genetic disorders," Cell 161(3): 647-660, 2015

Taipale et al, "A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways," Cell 158(2):434-448, 2014

Taipale et al, "Chaperones as thermodynamic sensors of drug-target interactions in living cells," Nature Biotechnology 31(7): 630-637, 2013.

Taipale et al, "Quantitative analysis of Hsp90-client interactions reveals modes of substrate recognition," Cell 150(5):987-1001, 2012.

Taipale, Jarosz, and Lindquist, "Hsp90 at the hub of protein homeostasis: emerging mechanistic insights," Nat. Rev. Mol. Cell Biol. 11(7):515-528, 2010

Connect

Appointment

CIFAR Azrieli Global Scholar Molecular Architecture of Life

Institution

University of TorontoDonnelly Centre for Cellular + Biomolecular Research - Department of Molecular Genetics

Education

PhD (Molecular Biology) University of Helsinki

MSc University of Oulu, Finland

Country

Canada

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