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Nicolas Corradi Genetics and heredity

In his research, Nicolas Corradi studies the content, structure and evolution gene of fungal genomes. His research focuses on two groups of fungi: evolutionary unrelated plan arbuscular mycorrhizal fungi and microsporidia. The research performed in this lab involves the evolutionary genomics of ecologically relevant and medically important fungi. In particular, the research focuses on two fungal organisms that are evolutionary unrelated but equally intriguing: the Arbuscular Mycorrhizal Fungi (AMF) and the Microsporidia. AMF represent an ecologically relevant group of ancient asexuals that form widespread symbioses with the roots of most land plants. These organisms have unusual cellular features, as each mycelium is composed of thousands of nuclei that coexist within one cytoplasm and by an elevated intracellular molecular diversity. The research aims to understand the origin and evolution of this peculiar polymorphism, and to acquire long-awaited insights into the content and structure of AMF genomes by comparing large genome and transcriptome sequence data. In parallel, a large chunk of our research focuses on the acquisition and comparative analysis of genomic data from a group of obligate intracellular parasites called Microsporidia. Most species of this group are characterized by miniaturized genomes, which we use as models to study the evolution of eukaryotic parasite genomes in a broad sense.

Awards

Young Investigator Award, International Conference on Opportunistic Protists, 2012.

Ontario Early Researcher Award

Relevant Publications

N. Corradi et al, "Gain and loss of multiple functionally-related horizontally transferred genes in the reduced genomes of two microsporidian parasites," Proc. Natl. Acad. Sci., vol. 109, no. 31, pp. 12638-12643, Jul. 2012.

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Appointment

Fellow Integrated Microbial Biodiversity

Institution

University of OttawaDepartment of Biology

Education

PhD (Molecular Evolution) University of Lausanne

BSc (Genetics and Molecular Biology) University of Geneva

Country

Canada

Ideas Related to Nicolas Corradi

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Integrated Microbial Biodiversity | News

Genome of ancient fungus unlocks secrets

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Integrated Microbial Biodiversity | News

Research team uncovers unusual changes in genomes of parasites

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