Paul Wiseman’s research interests lie at the interface between the physical and biological sciences. His work focuses on understanding the molecular mechanisms involved in how cells adhere to other cells and surfaces, and how cells regulate this adhesion to control cellular migration. He is also interested in developing new fluorescence fluctuation based biophysical methods, such as image correlation spectroscopy and spatial intensity distribution analysis to map protein transport and interactions in cells.
He is also working on application of nonlinear imaging modalities like second and third harmonic generation (SHG & THG) microscopy for live cell and fixed tissue imaging.
Fulbright Visiting Chair at the California NanoSystems Institute, UCLA, 2015.
J. D. Jackson Award for Excellence in Teaching (Physics), 2012.
Keith Laidler Award in Physical Chemistry, 2009.
Biophysical Society Young Fluorescence Investigator, 2005.
A. G. Godin et al, "Spatial intensity distribution analysis reveals abnormal oligomerization of proteins in single cells," Biophys. J., vol. 109, pp. 710-721, 2015.
A. Abu-arish et al, "Cholesterol modulates CFTR confinement in the plasma membrane of primary epithelial cells," Biophys. J., vol. 109, pp. 85-94, 2015.
L E. Lorenzo et al, "Gephyrin Clusters Are Absent from Small Diameter Primary Afferent Terminals Despite the Presence of GABAA Receptors," J. Neurosci., vol. 34, no. 24, pp. 8300-8317, June 2014.
K. E. Bujold et al, "Sequence-responsive unzipping DNA cubes with tunable cellular uptake profiles," Chem. Sci., vol. 5, no. 6, pp. 2449-2455, June 2014.
M. R. Khazaei et al, "Collapsin Response Mediator Protein 4 Regulates Growth Cone Dynamics through the Actin and Microtubule Cytoskeleton," J. Biol. Chem., vol. 289, no. 43, pp. 30133-30143, Oct. 2014.
Senior Fellow Molecular Architecture of Life
McGill UniversityDepartment of Physics; Department of Chemistry
PhD (Chemistry) University of Western Ontario
BSc (Honours Chemistry) St Francis Xavier University
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