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Philip Hieter Biochemist

Philip Hieter is recognized for his work on structural and regulatory proteins that ensure faithful segregation of chromosomes during cell division. His work has also demonstrated and advocated the value of yeast and other model experimental organisms for understanding mechanisms of human disease. Genes that maintain genome structure are often mutated in cancer. Hieter’s laboratory has established an extensive catalog of genes required for genome stability in yeast, that provides a resource to identify cross species, candidate human genes that are somatically mutated in cancer. His laboratory has developed a strategy to identify genes in yeast synthetic lethal interaction networks, based on yeast CIN genes whose human counterparts are mutated in cancers, as a means for identifying novel therapeutic targets for targeted killing of cancer cells.

Awards

Fellow, American Academy of Arts and Sciences, 2012.

President, Genetics Society of America, 2012.

Fellow, American Association for the Advancement of Science, 2005.

Fellow, Royal Society of Canada, 2005.

Fellow, American Academy of Microbiology, 1998.

Relevant Publications

R.S. Sikorski and P. Hieter, "A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae," Genetics, vol. 122, no. 1, pp. 19-27, 1989.

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Appointment

Senior Fellow Genetic Networks

Institution

University of British ColumbiaMichael Smith Laboratories

Education

PhD (Biochemistry) Johns Hopkins University

Country

Canada

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