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Sihyun Ham Chemistry

Sihyun Ham aims to understand why and how a normal cell becomes a disease cell at a molecular-level by using theoretical and computational methods. The main research effort is to develop and apply innovative computational methods for elucidating the mechanisms and driving factors of biomolecular interactions related to human diseases and cellular functions. These tools and new paradigm provide a unified view on how biomolecules operate and are applied to design a new function of specific interest in cellular network.


Fellow of the Royal Society of Chemistry, Royal Society of Chemistry, 2016.

The Scientist of the Month Award from the Korean Government, 2016.

The Female Scientists of the Year Award from the Korean Government, 2014.

Distinguished Lectureship Award from the Chemical Society of Japan, 2009.

Excellence in Research Award from Sookmyung Women’s University, Korea, 2009-2017.

Relevant Publications

S.-H. Chong, P. Chatterjee and S. Ham, "Computer Simulations of Intrinsically Disordered Proteins," Annu. Rev. Phys. Chem., vol. 68, pp. 117-134, 2017.

D. Fujiwara et al, "A Cyclized Helix-Loop-Helix Peptide as a Molecular Scaffold for the Design of Inhibitors of Intracellular Protein–Protein Interactions by Epitope and Arginine Grafting," Angew. Chem.-Int. Edit., vol. 55, no. 36, pp. 10612-10615, 2016.

C. L. Teoh et al, "Chemical Fluorescent Probe for Detection of Aβ Oligomers," J. Am. Chem. Soc., vol. 137, no. 42, pp. 13503-13509, 2015.

S.-H. Chong and S. Ham, "Distinct Role of Hydration Water in Protein Misfolding and Aggregation Revealed by Fluctuating Thermodynamics Analysis," Accounts Chem. Res., vol. 48, no. 4, pp. 956-965, 2015.

S.-H. Chong and S. Ham, "Interaction with the Surrounding Water Plays a Key Role in Determining the Aggregation Propensity of Proteins," Angew. Chem.-Int. Edit., vol. 53, no. 15, pp. 3961-3964, 2014.



Senior Fellow Molecular Architecture of Life


Sookmyung Women’s UniversityDepartment of Chemistry


Ph.D. Physical Organic Chemistry Texas Tech University

B.S. Chemistry Sookmyung Women’s University



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