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Timothy R. Hughes Molecular geneticist

Timothy Hughes’ laboratory has the fundamental goal of understanding how the genome is deciphered by cells, in human and other organisms. Often described as a “blueprint”, the genome is in fact a highly encoded instruction set – there is no simple mapping between the genome and the organism, and this shortcoming means that the function of the vast majority of the human genome is incomprehensible to us. As a first step, Hughes is decoding the sequences that are recognized by the thousands of proteins that bind DNA and RNA, and regulate gene activity, and using these data to build computational models of global gene regulation. A long-term goal of his research is to enable meaningful interpretation of human sequence variation and mutations, and to enable targeted modulation of cellular processes that are altered in disease.

Awards

Howard Hughes Medical Institute International Research Scholars Award, 2006.

Terry Fox Young Investigator Award, 2005.

Tier II Canada Research Chair in Genome Biology, 2002-2012.

Premier's Research Excellence Award, 2001.

Relevant Publications

N.J. Krogan et al, "Global landscape of protein complexes in the yeast Saccharomyces cerevisiae," Nature, vol. 440, no. 7084, pp. 637-643, 2006.

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Appointment

Senior Fellow Genetic Networks

Institution

University of TorontoDonnelly Centre for Cellular and Biomolecular Research

Education

PhD (Cell and Molecular Biology) Baylor College of Medicine

Country

Canada

Ideas Related to Timothy R. Hughes

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Disease-causing mutations are discovered in unexplored regions of the genome

Transformational new possibilities are opening up for medicine. The human splicing code reveals unexpected insights into the genetic origins of...

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Deep learning finds autism, cancer mutations in unexplored regions of the genome

Scientists and engineers have built a computer model that has uncovered disease-causing mutations in large regions of the genome that previously could not be explored.

Genetic Networks | News

‘Deep learning’ finds autism, cancer mutations in unexplored regions of the genome

A team led by CIFAR Senior Fellow Brendan Frey (University of Toronto) has built a computer model that has uncovered disease-causing...

Genetic Networks | News

Scientists decode mystery sequences involved in gene regulation

First-ever compendium of RNA sequences will be important guide to understanding the root of genetic diseases First-ever compendium of RNA...