Robert Waterston

Robert Waterston

Appointment

  • Advisor
  • Genetic Networks

Institution

  • University of Washington
Department of genome sciences

Country

  • United States

Education

PhD, University of Chicago
MD, University of Chicago
BEng, Princeton University

About

Through his leadership of the project to sequence the genome of the nematode Caenorhabditis elegans, geneticist Robert Waterston established methods and strategies that brought whole-genome sequencing of metazoans to reality.

His laboratory extended these to the human genome, constructing a clone-based physical map that served as the framework for the public Human Genome Project. Waterston’s leadership in that project was essential in fostering and maintaining the international collaboration. He also led projects to define what is conserved over evolution between mouse and human genomes, and what has changed between chimpanzee and human genomes. His laboratory also contributed to the initial human Single Nucleotide Polymorphism map. Through his efforts, all of this sequence is in the public domain without restriction, where it continues to foster discovery and medical advance. More recently, Waterston has directed his efforts toward discovering how the information stored in a genome produces a living organism. His own laboratory again focuses on the nematode C. elegans, developing new tools to understand the network of developmental control.

Awards

George W. Beadle Award, 2000
Gairdner Award, 2002
Dan David Prize, 2002
Alfred P. Sloan Jr. Prize, 2002
Gruber Prize in Genetics, 2005

Relevant Publications

Waterston, R.H. et al. "Initial sequencing and analysis of the mouse genome." Nature 420, no. 6915 (2002): 560–62.
International Human Genome Sequencing Consortium. "Initial sequencing and analysis of the human genome." Nature 409 (2001): 860–921.
International Human Genome Mapping Consortium. "A physical map of the human genome." Nature 409, no. 6822 (2001): 934–41.
International SNP Map Working Group. "A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms." Nature 409 (2001): 928–33.
C. elegans Sequencing Consortium. “Genome sequence of the nematode C. elegans: A platform for investigating biology.” Science 282 (1998): 2012–2018.

Connect

Waterston Lab